Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US5527527A · kind A · utility
140Cited by
18References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 15, 1993 |
| Grant date | Jun 18, 1996 |
| Priority date | — |
| Expiry date | Jan 15, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical or diagnostic agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical or diagnostic agent and methods for treating hosts afflicted with a disease associated with a neurological disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.