Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation
US5527713A · kind A · utility
29Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1995 |
| Grant date | Jun 18, 1996 |
| Priority date | — |
| Expiry date | Jul 19, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/56972
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated two aminodextrans containing about 5% and 16%, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.