Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5527856A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 1995 |
| Grant date | Jun 18, 1996 |
| Priority date | — |
| Expiry date | May 12, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L2666/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention am also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.