Stereodirected process for synthesis of .alpha.-N-acetylgalactosaminides
US5527891A · kind A · utility
2Cited by
6References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1994 |
| Grant date | Jun 18, 1996 |
| Priority date | — |
| Expiry date | Mar 9, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A stereodirected process for synthesizing .alpha.-N-acetylgalactosaminides from N-acetylgalactosamine which, in a preferred embodiment, comprises: PA1 reacting N-acetylgalactosamine with a dialkyl acetal of an aldehyde or ketone to form a 4,6-O-alkylidene derivative; PA1 reacting said 4,6-O-alkylidene derivative with a protecting group compound to attach a protecting group selectively to 3-OH of said derivative to form a 3-O-protected derivative; PA1 reacting said 3-O-protected derivative with an anomeric group to form a glycosyl donor; PA1 reacting said glycosyl donor with an alcohol to form an N-acetylgalactosaminide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.