Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
US5527901A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 1993 |
| Grant date | Jun 18, 1996 |
| Priority date | — |
| Expiry date | Dec 22, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The stereochemistry of sialylation of an acceptor saccharide to obtain an .alpha. (2-3) or .alpha. (2-6) linkage is controlled to favor the .alpha. anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate .alpha. (2-3) and .alpha. (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.