14.alpha., 17.alpha.-ethano-16.alpha.-hydroxy-estratrienes

US5529993A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerald Kirsch · Berlin, DE
• Gunter Neef · Berlin, DE
• Henry Laurent
• Rudolf Wiechert · Berlin, DE
• James R. Bull · Pretoria, ZA
• Peter Esperling · Berlin, DE
• Walter Elger · Berlin, DE
• Sybille Beier · Berlin, DE

Key dates

• Filing date: Nov 29, 1990
• Grant date: Jun 25, 1996
• Expiry date: Nov 29, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 14.alpha.,17.alpha.-bridged estratriene of formula I ##STR1## wherein (a) OR.sup.3 is in .alpha.-position PA1 R.sup.1, R.sup.2 and R.sup.3, each independently are (i) hydrogen, (ii) ##STR2## in which R.sup.4 is an organic radical with up to 11 carbon atoms or (iii) --(CH.sub.2).sub.n COOH wherein n=1-4, or (iv) R.sup.1 is a benzyl, C.sub.1 -C.sub.8 alkyl or C.sub.3 -C.sub.5 cycloalkyl, or PA1 (b) OR.sup.3 is in .beta.-position PA1 R.sup.1, R.sup.2 and R.sup.3, each independently are (i) hydrogen, (ii) an acyl group with 1 to 12 carbon atoms or (iii) R.sup.1 is C.sub.1 -C.sub.8 alkyl, and in both (a) and (b) A--B is an etheno or ethano bridge.