Sapphyrin chelator derivatives

US5530123A · kind A · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jonathan L. Sessler · Austin, US
• Brent L. Iverson · Austin, US
• Vladimir Kral · Austin, US
• Kevin Shreder · Austin, US
• Hiroyuki Furuta · Ooita, JP

Key dates

• Filing date: Oct 11, 1994
• Grant date: Jun 25, 1996
• Expiry date: Oct 11, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/101
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides various covalently modified sapphyrin derivatives and conjugates, and also, polymers including sapphyrin or derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; and polymer supported sapphyrins. Novel sapphyrin dimers, trimers, oligomers and polymers are also described, which polymers may include repeating units of sapphyrin or sapphyrin derivatives alone, or may further incorporate other units such as nucleobases.