Methods of detecting collagen degradation in vivo
US5532169A · kind A · utility
36Cited by
5References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 16, 1992 |
| Grant date | Jul 2, 1996 |
| Priority date | — |
| Expiry date | Jan 16, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/834
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. The method includes immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.