Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
US5532217A · kind A · utility
44Cited by
3References
10Claims
0Family size
Inventors
Key dates
| Filing date | Sep 7, 1995 |
| Grant date | Jul 2, 1996 |
| Priority date | — |
| Expiry date | Sep 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to effect nucleation and in-vitro growth of mineral crystals within and on the surface of the collagen fibers to form intact collagen fibers with subfibrillar substructure and wherein preparations of such mineralized collagen fibers are used in bone replacement therapy as well as to induce repair in bony defects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.