Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive glycosylation of different types of collagen and other proteins during diabetes

US5532227A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Lorne M. Golub · Smithtown, US
• Nungavarum S. Ramamurthy · Smithtown, US
• Thomas F. McNamara · Port Jefferson, US
• Maria Ryan · Port Jefferson Station, US

Key dates

• Filing date: Dec 21, 1994
• Grant date: Jul 2, 1996
• Expiry date: Dec 21, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating mammals suffering from excessive extracellular protein glycosylation which is associated with diabetes, scleroderma and progeria by administering to the mammal a tetracycline which effectively inhibits excessive protein glycosylation.