Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents

US5532228A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gunter Neef · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Andreas Stein-Eyer · Berlin, DE
• Katica Schwarz · Berlin, DE
• Matthias Brautigam · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Petra Rach · Berlin, DE

Key dates

• Filing date: Jun 1, 1993
• Grant date: Jul 2, 1996
• Expiry date: Jun 1, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C401/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention discloses side-chain homologous vitamin D derivatives of formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, B, and D have the meanings defined in the specification and either (1) A is a direct bond between carbon atoms 20 and 22 and X is an oxy alkylene radical, --(CH.sub.2).sub.n O-- where n is 1 to 3; (2) A is a methylene bridge, --CH.sub.2 --, between carbon atoms 20 and 22 and X is either an alkylene radical, --(CH.sub.2).sub.n -- or an oxy alkylene radical, --(CH.sub.2).sub.n O--, where n is 1 to 3; or (3) if A is a direct bond and B and D together form a second bond, then X(R.sup.5) (R.sup.6) is ##STR2## The compounds possess proliferation-inhibiting and cell-differentiating activity.