Piperidines and piperazines

US5532241A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Henning Bottcher · Darmstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Hartmut Greiner · Darmstadt, DE

Key dates

• Filing date: Sep 29, 1994
• Grant date: Jul 2, 1996
• Expiry date: Sep 29, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Piperidine and piperazine derivatives of the formula I ##STR1## wherein Ind is an indol-3-yl radical which is unsubstituted or mono- or polysubstituted by OH, OA, CN, Hal, COR.sup.2 or CH.sub.2 R.sup.2, PA1 R.sup.1 is benzofuran-5-yl or 2,3-dihydrobenzofuran-5-yl, chroman-6-yl, chroman-4-on-6-yl, 3-chromen-6-yl or chromen-4-on-6-yl, which is unsubstituted or monosubstituted by CN, CH.sub.2 OH, CH.sub.2 OA or COR.sup.2, PA1 Q is C.sub.m H.sub.2m, PA1 N or CR.sup.3, PA1 A is alkyl having 1-6 C atoms, PA1 Hal is F, C1, Br or I, PA1 R.sup.2 is OH, OA, NH.sub.2, NHA or NA.sub.2, PA1 R.sup.3 is H, OH or OA and PA1 m is 2, 3 or 4, and their physiologically acceptable salts, are active on the central nervous system.