Neurotransmitter releasers useful for cognition enhancement
US5532247A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 1995 |
| Grant date | Jul 2, 1996 |
| Priority date | — |
| Expiry date | Feb 23, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetylcholine and thus may be useful in the treatment of diseases learning and cognition. The compounds of this invention are ##STR1## where Q is ##STR2## A and B are independently selected from H, R.sup.4, --OH and --OCOR.sup.4, or PA1 A and B together form .dbd.O, .dbd.S, .dbd.CH.sub.2, .dbd.CHR.sup.4, .dbd.C(R.sup.4), .dbd.NOH, .dbd.NOR.sup.4, 1,3-dioxane, 1,3-dioxolane, 1,3-dithiane or 1,3-dithiolane; PA1 R.sup.1 is 4-,3-, or 2-pyridyl, 2-fluoro-4-pyridyl or 3-fluoro-4-pyridyl; PA1 R.sup.3, R.sup.4 and R.sup.5 are herein defined; and physiologically suitable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.