O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity
US5532248A · kind A · utility
49Cited by
23References
3Claims
0Family size
Assignee
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Key dates
| Filing date | May 12, 1995 |
| Grant date | Jul 2, 1996 |
| Priority date | — |
| Expiry date | May 12, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.