Acrylacetamides

US5532266A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rudolf Gottschlich · Reinheim, DE
• Karl-August Ackermann · Ober-Ramstadt, DE
• Helmut Prucher · Heppenheim, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Hartmut Greiner · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Frank Mauler · Seeheim-Jugenheim, DE
• Manfred Stohrer · Mainz, DE
• Andrew Barber · Weiterstadt, DE

Key dates

• Filing date: May 30, 1995
• Grant date: Jul 2, 1996
• Expiry date: May 30, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel arylacetamides of the formula I ##STR1## in which Q is R.sup.4 --CH(CH.sub.2 Z)--NA--, ##STR2## R.sup.1 is Ar, cycloalkyl with 3-7 C atoms or C.sub.4 -C.sub.8 -cycloalkyl-C.sub.1 -C.sub.7 -alkyl, PA1 R.sup.2 is Ar, PA1 R.sup.3 is H, OH, OA or A, PA1 R.sup.4 is A or phenyl which can optionally be substituted once or twice by F, Cl, Br, I, OH, OA, CF.sub.3, NO.sub.2, NH.sub.2, NHA, NHCOA, NHSO.sub.2 A or NA.sub.2, PA1 R.sup.5 and R.sup.6 are each, independently of one another, H, F, Cl, Br, I, OH, OA, CF.sub.3, NH.sub.2, NHA, NA.sub.2, NHCOA, NHCONH.sub.2, NO.sub.2 or taken together are methylenedioxy, PA1 A is alkyl with 1-7 C atoms, and physiologically acceptable salts thereof.