Benzothiophenes substituted at the 3-carbonyl

US5532382A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Donald G. Carlson · Indianapolis, US
• George J. Cullinan · Trafalgar, US
• Kennan J. Fahey · Indianapolis, US
• William T. Jackson · Indianapolis, US
• Neal W. Roehm · Zionsville, US
• Stephen M. Spaethe · Carmel, US

Key dates

• Filing date: Mar 13, 1995
• Grant date: Jul 2, 1996
• Expiry date: Mar 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are compounds of the formula II ##STR1## wherein R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1 -C.sub.6 alkyl; PA1 R.sub.5 is naphthyl, substituted nephthyl, or phenyl substituted one to three times with C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, phenyl, or hydroxy; with the proviso that if the phenyl is substituted once with hydroxy, it must be further be substituted once or twice with C.sub.1 -C.sub.6 alkoxy, C.sub.l -C.sub.6 alkyl, phenyl or hydroxy, and pharmaceutically acceptable salts thereof.