Method of preparing stable drug nanoparticles
US5534270A · kind A · utility
236Cited by
2References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 9, 1995 |
| Grant date | Jul 9, 1996 |
| Priority date | — |
| Expiry date | Feb 9, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/915
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclaving and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.