Therapeutic nucleosides

US5534535A · kind A · utility

Assignees

• Burroughs Wellcome Co. · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Leroy B. Townsend · Ann Arbor, US
• John C. Drach · Ann Arbor, US
• Steven Good · Durham, US
• Susan Mary Daluge · Chapel Hill, US
• Michael Tolar Martin · Durham, US

Key dates

• Filing date: Sep 9, 1994
• Grant date: Jul 9, 1996
• Expiry date: Sep 9, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-, 5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.