N-acyl dipeptides and their compositions

US5534538A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Gunter Knaup · Bruchköbel, DE
• Ulrich Groeger · Aschaffenburg, DE

Key dates

• Filing date: Feb 10, 1994
• Grant date: Jul 9, 1996
• Expiry date: Feb 10, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel a-acyl dipeptides of the formula: EQU R.sup.2 --NH--CHR.sup.1 --O--AS in which AS, R.sup.1 and R.sup.2 have certain, more precisely defined meanings. These N-acyl dipeptides are more stable under conditions of sterilization (121.degree. C.) than corresponding, non-acylated dipeptides. On the other hand, they are cleaved more rapidly and more completely at the peptide bond in the living organism than the cleavage of the acyl group from simple N-acyl amino acids takes place. They can therefore be used with advantage as a source for the carbon terminal amino acid in mixtures and solutions for artificial nutrition or in culture media for cell cultures.