Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor
US5534540A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 20, 1993 |
| Grant date | Jul 9, 1996 |
| Priority date | — |
| Expiry date | Jul 20, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/922
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.