Methods for identifying a tyrosine phosphatase abnormality associated with neoplastic disease
US5536636A · kind A · utility
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8Claims
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Key dates
| Filing date | Feb 28, 1994 |
| Grant date | Jul 16, 1996 |
| Priority date | — |
| Expiry date | Feb 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i.e., increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.