Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
US5536639A · kind A · utility
9Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1994 |
| Grant date | Jul 16, 1996 |
| Priority date | — |
| Expiry date | Mar 25, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6896
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.