Phosphonosuccinic acid derivatives, processes for their preparation and medicaments containing these compounds

US5538957A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christos Tsaklakidis · Weinheim, DE
• Elmar Bosies · Weinheim, DE
• Angelika Esswein · Büttelborn, DE
• Frieder Bauss · Lambsheim, DE

Key dates

• Filing date: Jun 3, 1994
• Grant date: Jul 23, 1996
• Expiry date: Jun 3, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6506
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) in which: R is a possibly substituted amino group of the general form --NR.sub.1 R.sub.2, in which R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, lower alkenyl or lower alkinyl, or R is a saturated, unsaturated or aromatic heterocyclic ring which may be mono or bi-substituted by lower alkyl or halogen; alk is a valency bond, a methylene, a saturated or unsaturated, straight or branched-chain alkylene chain with 2-6 carbon atoms; and R.sup.3, R.sup.4, R.sup.5 are independently hydrogen, lower alkyl or benzyl; and their pharmacologically acceptable salts and enantiomers where, if R.sup.3 .dbd.R.sup.4 .dbd.R.sup.5 .dbd.CH.sub.3 and alk is a valency bond, R may not be the dimethyl amino group. Process for their production and medicaments containing these compounds, for the treatment of calcium metabolic complaints.