Patent · US Expired

Process for resolution of racemates of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters

US5539111A · kind A · utility

7Cited by

6References

6Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Karl Petzoldt · Berlin, DE
Ralph Schmiechen · Berlin, DE
Kurt Hamp · Berlin, DE
Matthias Gottwald · Berlin, DE

Key dates

Filing date	Feb 18, 1993
Grant date	Jul 23, 1996
Priority date	—
Expiry date	Feb 18, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P41/005
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An enzymatic process employing pancreatin or choelsterol esterase for resolution of racemates of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters of general formula I ##STR1## in which X represents a carbon-carbon bond or an oxygen atom, PA1 R.sub.1 means a hydrocarbon radical optionally substituted by hydroxy groups, oxo groups and/or halogen atoms and/or interrupted by nitrogen atoms with at most 16 carbon atoms, PA1 R.sub.2 symbolizes an alkyl group with up to 4 carbon atoms and PA1 R.sub.3 represents an alkyl group with at most 6 carbon atoms is described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.