Calcitonin derivatives

US5541159A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Rainer Albert · Basel, CH
• Wilfried Bauer · Lampenberg, CH
• Francois Cardinaux · Reinach, CH
• Janos Pless · Basel, CH

Key dates

• Filing date: Nov 29, 1994
• Grant date: Jul 30, 1996
• Expiry date: Nov 29, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptide derivatives selected from (i) a calcitonin peptide and a LHRH antagonist peptide modified by at least one sugar residue and/or at least one short polyhydroxy compound or derivative, and (ii) a calcitonin peptide modified by at least one formyl and/or at least C.sub.3-5 alkyl attached to an amino group other than a N-terminal amino group, and (iii) a calcitonin peptide modified by a combination of said substituents, with the provisos that PA1 i) when the calcitonin peptide comprises at least one sugar residue a), this sugar residue is attached by a coupling other than a direct N-glycosidic bond to an .omega.-amino group of an .omega.-amino substituted side chain in the 24 position, and PA1 ii) when the LHRH antagonist comprises at least one sugar residue a), this sugar residue is an Amadori sugar residue attached by a coupling other than a direct N-glycosidic bond to an .omega.-amino group of an .omega.-amino substituted side chain in the 8 position in free form or in salt or complex form, have pharmacological activity.