Patent · US Expired

Orally administrable pharmaceutical compositions

US5541170A · kind A · utility

79Cited by
9References
7Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 10, 1995
Grant dateJul 30, 1996
Priority date—
Expiry dateMar 10, 2015

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P29/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A solid dosage form, such as a capsule or tablet, containing a pharmacologically active agent is coated with an anionic polymer, which is insoluble in gastric juice and in intestinal juice below pH7 but soluble in colonic intestinal juice, in a sufficient amount that the oral dosage form remains intact until it reaches the colon. The preferred anionic polymer is a partly methyl esterified methacrylic acid polymer in which the ratio of free carboxylic groups to ester groups is about 1:2. The invention has particular application to dosage forms of prednisolone and salts thereof, indomethacin, ibuprofen, and, especially, 5-amino-salicylic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.