Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors
US5541218A · kind A · utility
2Cited by
2References
8Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 24, 1995 |
| Grant date | Jul 30, 1996 |
| Priority date | — |
| Expiry date | Mar 24, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain indoline derivatives of the formula I: ##STR1## wherein the variables Y, A, R.sub.1, R.sub.4 and n have the definitions set forth in the disclosure, have the ability to inhibit the 5-lipoxygenase enzyme. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.