Treatment of multidrug resistant diseases
US5541232A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1994 |
| Grant date | Jul 30, 1996 |
| Priority date | — |
| Expiry date | Jun 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/243
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method and composition for treating multidrug resistance in a mammal, in which the composition includes NDGA or an analog of NDGA in accordance with the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently H, lower alkyl or lower acyl; PA1 R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are independently H or lower alkyl; PA1 R.sub.7, R.sub.8 and R.sub.9 are independently H, hydroxy, lower alkoxy or lower acyloxy; and PA1 R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are independently H or lower alkyl, in a pharmaceutically acceptable vehicle. The method is particularly suitable for administering an antineoplastic agent, and the composition includes the combination of NDGA, or an analog with such an antineoplastic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.