Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane

US5541328A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Timothy Lee Stuk · Mattawan, US
• Michael S. Allen · Spooner, US
• Anthony R. Haight · Wadsworth, US
• Francis A. J. Kerdesky · Grayslake, US
• Denton C. Langridge · Wildwood, US
• M. Robert Leanna · Grayslake, US
• Linda M. Lijewski · Milwaukee, US
• Laura Melcher · Deerfield, US
• Howard E. Morton · Gurnee, US
• Daniel W. Norbeck · Crystal Lake, US
• Daniel S. Reno · Kenosha, US
• Timothy A. Robbins · Gurnee, US
• Hing L. Sham · South San Francisco, US
• Thomas J. Sowin · Grayslake, US
• Jien-Heh J. Tien · Libertyville, US
• Chen Zhao · Gurnee, US
• David Scarpetti · Baltimore, US

Key dates

• Filing date: Apr 3, 1995
• Grant date: Jul 30, 1996
• Expiry date: Apr 3, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A substantially pure compound of formula: ##STR1## wherein R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or PA1 R.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl; or PA1 R.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; and PA1 R.sub.g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.