Sphingosomes for enhanced drug delivery
US5543152A · kind A · utility
187Cited by
2References
15Claims
0Family size
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Key dates
| Filing date | Jun 20, 1994 |
| Grant date | Aug 6, 1996 |
| Priority date | — |
| Expiry date | Jun 20, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1272
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.