Method of detecting carcinoma
US5543291A · kind A · utility
18Cited by
2References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1993 |
| Grant date | Aug 6, 1996 |
| Priority date | — |
| Expiry date | Jan 29, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/813
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. Altered expression of cyclins, such as overproduction of cyclins, particularly cyclin E, or production of alternative cyclin E proteins, as well as deranged appearance of mitotic cyclins during the cell cycle, are indicative of the presence of carcinoma. Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma.
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