Adenoviruses having modified fiber proteins
US5543328A · kind A · utility
82Cited by
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35Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 13, 1993 |
| Grant date | Aug 6, 1996 |
| Priority date | — |
| Expiry date | Aug 13, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/853
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.