Acyclic amidine group-containing diphosphonic acid derivatives, processes for their preparation and medicaments containing these compounds

US5543561A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Harald Zilch · Mannheim, DE
• Frieder Bauss · Lambsheim, DE

Key dates

• Filing date: Mar 28, 1995
• Grant date: Aug 6, 1996
• Expiry date: Mar 28, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## in which R.sup.1 signifies hydrogen, a straight-chained, branched, saturated or unsaturated alkyl radical with 1-9 carbon atoms possibly substituted by phenyl or a phenyl ring which is possibly substituted by C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 -alkoxy or halogen, R.sup.2 signifies hydrogen or C.sub.1 -C.sub.3 -alkyl, whereby the two radicals can be the same or different, R represents hydrogen or a straight-chained or branched alkyl radical with 1-4 carbon atoms, X signifies an alkylene chain with 1-6 carbon atoms which can be substituted one or more times by C.sub.1 -C.sub.3 -alkyl and can possibly be interrupted by oxygen, whereby 1 or 2 carbon stems of the alkylene chain can possibly be part of a cyclopentyl or cyclohexyl ring and Y signifies hydrogen, hydroxyl or amino group possibly substituted by alkyl groups with 1-6 carbon atoms, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medicaments for the treatment of calcium metabolism disturbances.