Glutathione S-transferase-activated compounds
US5545621A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 1, 1993 |
| Grant date | Aug 13, 1996 |
| Priority date | — |
| Expiry date | Oct 1, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91177
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compounds of the formula: ##STR1## or the amides, esters or salts thereof, wherein: L is an electron withdrawing leaving group; S.sup.x is S=O, O=S=O, S=NH, HN=S=O, Se=O, O=Se=O, Se=NH, HN=Se=O, S+R.sup.4 wherein R.sup.4 is alkyl (1-6 C), or O--C=O or HN--C=O; each R of R.sup.1, R.sup.2 and R.sup.3 is independently H or a noninterfering substituent; n is 0, 1 or 2; Y is selected from the group consisting of ##STR2## wherein m is 1 or 2; and AA.sub.C is an amino acid linked through a peptide bond to the remainder of said compound of formula 1, are dislosed. These compounds are useful prodrugs for selective treatment of target tissues which contain compatible glutathione S-transferase (GST) isoenzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.