Protein kinase C inhibitors

US5545636A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• William F. Heath, Jr. · Fishers, US
• John H. McDonald, III · Carmel, US
• Michael Paal · Hamburg, DE
• Gerd R uhter · Hamburg, DE
• Theo Schotten · Winsen (Luhe), DE
• Wolfgang Stenzel · Reinbek, DE

Key dates

• Filing date: Oct 18, 1994
• Grant date: Aug 13, 1996
• Expiry date: Oct 18, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention discloses compounds of the general formula: ##STR1## The compounds are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.