Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthridonecarboxylic acid

US5545642A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Uwe Petersen · Leverkusen, DE
• Thomas Schenke · Odenthal, DE
• Stefan B ohm · Krefeld, DE
• Rolf Grosser · Schwandorf, DE
• Klaus-Dieter Bremm · Recklinghausen, DE
• Rainer Endermann · Wuppertal, DE
• Karl G. Metzger · Wuppertal, DE

Key dates

• Filing date: Nov 9, 1994
• Grant date: Aug 13, 1996
• Expiry date: Nov 9, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid which are substituted in the 7 position by a 2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl or 1,2,3,4,5,6-hexahydropyrrolo[3,4-c]pyrrol-2-yl residue, to their salts, to a process for their preparation and to antibacterial agents containing these derivatives.