Muteins of IFN-.beta.
US5545723A · kind A · utility
19Cited by
18References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 1994 |
| Grant date | Aug 13, 1996 |
| Priority date | — |
| Expiry date | Mar 15, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods of using those compositions to treat viral infections, cancer or tumors or for immunomodulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.