Retroviral protease inhibiting compounds

US5545750A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Dale J. Kempf · Libertyville, US
• Daniel W. Norbeck · Crystal Lake, US
• John W. Erickson · Barrington, US
• Hing L. Sham · South San Francisco, US
• Lynn M. Codacovi · Antioch, US
• Jacob J. Plattner · Libertyville, US

Key dates

• Filing date: Mar 23, 1995
• Grant date: Aug 13, 1996
• Expiry date: Mar 23, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A retroviral protease inhibiting compound of the formula EQU A--X--B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; PA1 A is PA2 (1) substituted amino, PA2 (2) substituted carbonyl, PA2 (3) functionalized imino, PA2 (4) functionalized alkyl, PA2 (5) functionalized acyl, PA2 (6) functionalized heterocyclic or PA2 (7) functionalized (heterocyclic)alkyl; and PA1 B is PA2 (1) substituted carbonyl independently defined as herein, PA2 (2) substituted amino independently defined as herein, PA2 (3) functionalized imino independently defined as herein, PA2 (4) functionalized alkyl independently defined as herein, PA2 (5) functionalized acyl independently defined as herein, PA2 (6) functionalized heterocyclic independently defined as herein or PA2 (7) functionalized (heterocyclic)alkyl independently defined as herein.