Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, DNA encoding them, and expression of the DNA in transformed cells
US5547855A · kind A · utility
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Key dates
| Filing date | Mar 15, 1995 |
| Grant date | Aug 20, 1996 |
| Priority date | — |
| Expiry date | Mar 15, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/70571
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Disclosed is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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