Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it
US5547944A · kind A · utility
9Cited by
4References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 23, 1994 |
| Grant date | Aug 20, 1996 |
| Priority date | — |
| Expiry date | Feb 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A natural dermatan sulphate with antithrombinic activity in excess of 220 U/mg which comprises an oligosaccharide sequence with a high degree of sulfation, having formula (III) ##STR1## in which: n=integers 1 or 2; R.sub.4 =SO.sub.3, or H; R.sub.6 =H, or SO.sub.3 ; G=glucuronic acid: I--non-sulfated uronic acid, preferably glucuronic acid, is extracted from organs, and subsequently purified in mild operating conditions, at pH 5-7, isolation and fractionation being carried out with macroreticular ion exchange resins, having a particle size of less than 10 .mu..
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.