Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5549904A · kind A · utility
142Cited by
6References
36Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 3, 1993 |
| Grant date | Aug 27, 1996 |
| Priority date | — |
| Expiry date | Jun 3, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.