Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof

US5550111A · kind A · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Robert J. Suhadolnik · Roslyn, US
• Wolfgang Pfleiderer · Konstanz, DE

Key dates

• Filing date: Nov 3, 1994
• Grant date: Aug 27, 1996
• Expiry date: Nov 3, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J51/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.