Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines

US5550132A · kind A · utility

Assignees

• University of North Carolina · US
• Macronex, Inc. · US

Inventors

• Bradley J. Benson · Chapel Hill, US
• Xiannong Chen · Athens, US
• George J. Cianciolo · Durham, US
• Jose-Luis Diaz · San Jose, US
• Khalid S. Ishaq · Chapel Hill, US
• Susan L. Morris-Natschke · Apex, US
• Ronald J. Uhing · Durham, US
• Henry Wong · Candiac, CA

Key dates

• Filing date: Jun 22, 1994
• Grant date: Aug 27, 1996
• Expiry date: Jun 22, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.