Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5550233A · kind A · utility
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Key dates
| Filing date | Jun 21, 1994 |
| Grant date | Aug 27, 1996 |
| Priority date | — |
| Expiry date | Jun 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and alkylation at C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.