Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
US5550239A · kind A · utility
1Cited by
1References
13Claims
0Family size
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Key dates
| Filing date | Nov 8, 1994 |
| Grant date | Aug 27, 1996 |
| Priority date | — |
| Expiry date | Nov 8, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved, novel convergent process suitable for large scale preparation of the antimigraine agent 4-(5-methoxy-4-pyrimidinyl)-1-[3-[5-[[(methylamino)sulfonyl]methyl]-1H-ind ol-3-yl]propyl]piperazine (BMS 180048) and close analogs. The improved process provides efficiencies in handling, purification, and product yield and involves a novel heteroannulation reaction that provides the indole ring moiety and propylpiperazinyl-pyrimidine backbone in a single step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.