Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent
US5552133A · kind A · utility
157Cited by
6References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 12, 1994 |
| Grant date | Sep 3, 1996 |
| Priority date | — |
| Expiry date | Aug 12, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Encapsulated gas microspheres useful as an ultrasonic imaging agent are made by: mixing an aqueous solution of a heat-denaturable protein with a gas, and passing the gas-solution mixture through a mill whereby the mixture is emulsified near the denaturation temperature of the protein and subjected to mechanical shearing and cavitation which causes the formation of gas bubbles in the 0.1 to 10 micron range, and the protein to locally denature and deposit at the gas-liquid interface to form the encapsulated microspheres.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.