Solid depot drug form

US5552159A · kind A · utility

Assignee

• BASF SE

Inventors

• Winfried Mueller · Mannheim, DE
• Reinhard Spengler · Frankenthal (Pfalz), DE
• Sven Grabowski · Ludwigshafen, DE
• Axel Sanner · Bischofswerda, DE

Key dates

• Filing date: Sep 23, 1993
• Grant date: Sep 3, 1996
• Expiry date: Sep 23, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2054
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid depot drug form produced by melt extrusion at from 50.degree. to 200.degree. C. and continuous shaping of a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutical active ingredient with a polymer melt of the following composition: PA1 a) at least 6% by weight, based on the complete depot form, of at least one water-insoluble poly(meth) acrylate with a glass transition temperature Tg in the range from -60.degree. to 180.degree. C., PA1 b) a water-soluble hydroxyalkylcellulose or hydroxy-alkylmethylcellulose with 2 or 3 carbons in the hydroxyalkyl, or an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or a mixture of the two in the ratio a):b) =5:95 to 95:5, and PA1 c) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries.