Surface modified NSAID nanoparticles

US5552160A · kind A · utility

Assignee

• Nano Systems L.L.C. · US

Inventors

• Gary Liversidge · West Chester, US
• Philip Conzentino, Jr. · West Chester, US
• Kenneth C. Cundy · Redwood City, US
• Pramod Sarpotdar · Malvern, US

Key dates

• Filing date: Mar 13, 1995
• Grant date: Sep 3, 1996
• Expiry date: Mar 13, 2015

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric irritation following oral administration and/or hastened onset of action.