Solution for prolonged organ preservation

US5552267A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• David M. Stern · Great Neck, US
• Mehmet C. Oz · Cliffside Park, US
• Roman Nowygrod · Teaneck, US
• Shin Koga · New York, US
• David Pinsky · Yonkers, US

Key dates

• Filing date: Dec 5, 1994
• Grant date: Sep 3, 1996
• Expiry date: Dec 5, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01N1/126
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

An aqueous solution for organ preservation or maintenance, which contains: a vasodilator in an amount sufficient to maintain vascular homeostasis; D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability; potassium ions in a concentration greater than about 110 mM; and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about physiologic pH or above.