Process for the preparation of 2-ethoxy-4,6-dihydroxypyrimidine
US5552546A · kind A · utility
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Key dates
| Filing date | Jul 28, 1994 |
| Grant date | Sep 3, 1996 |
| Priority date | — |
| Expiry date | Jul 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A salt of 2-ethoxy-4,6-dihydroxypyrimidine (DHEP) is prepared by contacting a salt of O-ethylisourea with dimethyl malonate in the presence of a methoxide base to form the salt of DHEP. The salt of DHEP can optionally be protonated with an acid to form neutral DHEP. The reaction is typically conducted in a methanol solvent at a temperature less than about 30.degree. C. Typically, the monosodium salt of DHEP is prepared by contacting O-ethylisourea hydrochloride with dimethyl malonate in the presence of sodium methoxide and methanol solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.